10.4225/03/5a13709f243b5
Higgs, Trent
Trent
Higgs
Stantic, Bela
Bela
Stantic
Hoque, Md Tamjidul
Tamjidul
Hoque
Sattar, Abdul
Abdul
Sattar
Hydrophobic-hydrophilic forces and their effects on protein structural similarity
Monash University
2017
Bioinformatics -- Congresses
Computational biology -- Congresses
Computer vision in medicine -- Congresses
Computational biology -- Methods -- Congresses
Pattern recognition, automated -- Methods -- Congresses
2008
conference paper
1959.1/63678
monash:7847
Bioinformatics Software
Bioinformatics
Pattern Recognition and Data Mining
2017-11-21 00:16:18
Dataset
https://bridges.monash.edu/articles/dataset/Hydrophobic-hydrophilic_forces_and_their_effects_on_protein_structural_similarity/5619460
Hydrophobic-hydrophilic interactions have a strong impact on the three-dimensional structure a protein will adopt. Because structure, not amino acid sequence order, carry out certain functions it is important to understand how these forces affect the protein folding process. In recent years, a lot of focus has been dedicated towards ab initio protein folding prediction, which tries to predict a proteins native conformation from its sequence alone. To aid this type of prediction sub-conformations from already known proteins are used to limit the free energy conformational search space. In this paper we looked into the sub-conformations’ hydrophobic-hydrophilic nature by incorporating a HP approach and proposed a way of evaluating how these type of forces affect the protein folding process. By doing this, we can gain insight into how hydrophobic-hydrophilic interactions affect protein structural similarity, and thus aid us in picking more suitable sub-conformations based off their HP shape for use in protein structure prediction. PRIB 2008 proceedings found at: http://dx.doi.org/10.1007/978-3-540-88436-1
Contributors: Monash University. Faculty of Information Technology. Gippsland School of Information Technology ;
Chetty, Madhu ;
Ahmad, Shandar ;
Ngom, Alioune ;
Teng, Shyh Wei ;
Third IAPR International Conference on Pattern Recognition in Bioinformatics (PRIB) (3rd : 2008 : Melbourne, Australia) ;
Coverage:
Rights: Copyright by Third IAPR International Conference on Pattern Recognition in Bioinformatics. All rights reserved.