The Pathological Role of Cell Division Autoantigen 1 (CDA1) in renal fibrosis
PACIFIC HUYNH
10.26180/5b42aeba2c995
https://bridges.monash.edu/articles/thesis/The_Pathological_Role_of_Cell_Division_Autoantigen_1_CDA1_in_renal_fibrosis/6790712
Cell Division Autoantigen 1 (CDA1) has been validated as a potential target to treat diabetic patients with kidney disease. My project was to further examine the role of CDA1 in a scenario similar to the clinical setting were I experimentally targeted CDA1 after the disease has been established. Indeed, my study confirms that targeting CDA1 at early stages of diabetic kidney disease was effective in reducing kidney scarring in experimental diabetic mice.
2018-07-09 00:39:20
Renal Fibrosis
Transforming growth factor beta (TGFβ)
Cell Division Autoantigen 1 (CDA1)
Diabetic Nephropathy
Inducible Genetic Deletion
Pathology
Biochemistry and Cell Biology not elsewhere classified