A functional and structural investigation of the pro- and anti-viral roles of the DDX3 DEAD-box RNA helicases
STEVEN MATTHEW HEATON
10.26180/5b751cdc58ac1
https://bridges.monash.edu/articles/thesis/A_functional_and_structural_investigation_of_the_pro-_and_anti-viral_roles_of_the_DDX3_DEAD-box_RNA_helicases/6973754
During infection, our immune system triggers drastic but highly regulated changes in gene activity to bring about protective immune responses. This thesis identifies, dissects and challenges the molecular mechanisms by which DDX3 interacts with the cell nucleus and controls the two main signalling and effector arcs of the human innate immune system. Several incurable viruses weaponise DDX3 and thereby hack into a nexus of immune and other cellular functions to service their own replication; we now adapt this concept and turn it against these very viruses to develop new treatments.
2018-08-16 06:42:34
CRM1
IFN-I
immune signalling
NF-kB
nuclear transport
post-translational modification
RLR
TRIM
ubiquitin
virus
Biochemistry
Virology
Cell Biology
Molecular Biology
Proteins and Peptides
Protein Trafficking
Signal Transduction
Structural Biology (incl. Macromolecular Modelling)
Innate Immunity