A functional and structural investigation of the pro- and anti-viral roles of the DDX3 DEAD-box RNA helicases STEVEN MATTHEW HEATON 10.26180/5b751cdc58ac1 https://bridges.monash.edu/articles/thesis/A_functional_and_structural_investigation_of_the_pro-_and_anti-viral_roles_of_the_DDX3_DEAD-box_RNA_helicases/6973754 During infection, our immune system triggers drastic but highly regulated changes in gene activity to bring about protective immune responses. This thesis identifies, dissects and challenges the molecular mechanisms by which DDX3 interacts with the cell nucleus and controls the two main signalling and effector arcs of the human innate immune system. Several incurable viruses weaponise DDX3 and thereby hack into a nexus of immune and other cellular functions to service their own replication; we now adapt this concept and turn it against these very viruses to develop new treatments. 2018-08-16 06:42:34 CRM1 IFN-I immune signalling NF-kB nuclear transport post-translational modification RLR TRIM ubiquitin virus Biochemistry Virology Cell Biology Molecular Biology Proteins and Peptides Protein Trafficking Signal Transduction Structural Biology (incl. Macromolecular Modelling) Innate Immunity