10.26180/5be8e6eabbb61
SHADABUL HAQUE
SHADABUL
HAQUE
Understanding the Lung Clearance Kinetics and Disposition of Inhaled Biodegradable Nanomedicines
Monash University
2018
Pulmonary
Clearance
Inhalation
Pharmacokinetics
Liposome
PLGA
SLN
Lung inflammation
Pharmaceutical Sciences
2018-11-12 02:35:21
Thesis
https://bridges.monash.edu/articles/thesis/Understanding_the_Lung_Clearance_Kinetics_and_Disposition_of_Inhaled_Biodegradable_Nanomedicines/7325897
Inhalable nanomedicines based on biodegradable lipid- or polymer-based nanomaterial drug carriers are rapidly being advanced through preclinical and clinical trials. Despite this, there is still a fundamental lack of understanding about how biodegradable or erodible nanoparticles and polymeric drug carriers are cleared from healthy and diseased lungs. This thesis comprehensively evaluates the pharmacokinetic behavior, patterns of lung clearance and immunological responses of the lungs to inhaled biodegradable nanoparticles that have been extensively explored pre-clinically as inhalable nanomedicines. This thesis also describes and compares the biopharmaceutical behaviour of inhaled nanomedicines in healthy and diseased lungs.