10.26180/5bf208045df27
ELIZABETH ANNE SIGSTON
ELIZABETH ANNE
SIGSTON
Emergence and Margins in Head and Neck Cancer: A new understanding
Monash University
2019
carcinogenesis
emergence
systems biology
oral cancer
complexity
cancer biology
head and neck cancer
squamous cell carcinoma
epithelial mesenchymal transition
p63
vimentin
laminin gamma2
dual immunohistochemistry
Cancer
Surgery
Oncology and Carcinogenesis not elsewhere classified
Oral and Maxillofacial Surgery
Oral Medicine and Pathology
Systems Biology
2019-03-13 22:18:13
Thesis
https://bridges.monash.edu/articles/thesis/Emergence_and_Margins_in_Head_and_Neck_Cancer_A_new_understanding/7357226
Cancer has been widely accepted as a genetic disease. This thesis challenges this assumption and proposes that cancer be considered as an emergent complex system. A new framework for carcinogenesis and cancer progression is presented. This framework is applied to identify biological markers with the potential to predict recurrence in oral cancer. A simple dual staining technique is developed to test the identified biomarkers. The results support the use of these biomarkers as a predictor of recurrence over and above traditionally measured cancer clearance.