SIGSTON, ELIZABETH ANNE Emergence and Margins in Head and Neck Cancer: A new understanding Cancer has been widely accepted as a genetic disease. This thesis challenges this assumption and proposes that cancer be considered as an emergent complex system. A new framework for carcinogenesis and cancer progression is presented. This framework is applied to identify biological markers with the potential to predict recurrence in oral cancer. A simple dual staining technique is developed to test the identified biomarkers. The results support the use of these biomarkers as a predictor of recurrence over and above traditionally measured cancer clearance. carcinogenesis;emergence;systems biology;oral cancer;complexity;cancer biology;head and neck cancer;squamous cell carcinoma;epithelial mesenchymal transition;p63;vimentin;laminin gamma2;dual immunohistochemistry;Cancer;Surgery;Oncology and Carcinogenesis not elsewhere classified;Oral and Maxillofacial Surgery;Oral Medicine and Pathology;Systems Biology 2019-03-13
    https://bridges.monash.edu/articles/thesis/Emergence_and_Margins_in_Head_and_Neck_Cancer_A_new_understanding/7357226
10.26180/5bf208045df27