%0 Thesis %A SPICER, BRADLEY ALAN %D 2019 %T A biochemical characterisation of the MACPF/CDC pore assembly %U https://bridges.monash.edu/articles/thesis/A_biochemical_characterisation_of_the_MACPF_CDC_pore_assembly/7545266 %R 10.26180/5c2ece643e8b7 %2 https://bridges.monash.edu/ndownloader/files/14565575 %K MACPF %K Complement %K Membrane Attack Complex %K Complement component-9 %K Pore forming proteins %K Biochemistry %X The blood plasma contains vital immune proteins for defending against bacteria. This thesis determines high-resolution structures of a giant pore forming protein in the plasma called the Membrane Attack Complex (MAC). Furthermore, a biochemical examination provides a mechanism of how MAC proteins assemble, and an improved understanding of the immune system. %I Monash University