10.26180/5c3494e1e0e9c
PARIS CLARICE PAPAGIANIS
PARIS CLARICE
PAPAGIANIS
Anti-inflammatory therapies for bronchopulmonary dysplasia
Monash University
2019
chorioamnionitis
glucocorticoid
dexamethasone
stem cells
pulmonary
inflammation
bronchopulmonary dysplasia
Physiology
Paediatrics
2019-03-12 02:42:38
Thesis
https://bridges.monash.edu/articles/thesis/Anti-inflammatory_therapies_for_bronchopulmonary_dysplasia/7558886
Bronchopulmonary dysplasia is a potentially fatal chronic lung disease that represents the principal cause of morbidity in infants born before 28 weeks of gestation. Both antenatal inflammation and mechanical ventilation are common antecedents that contribute to this condition. This thesis studies the effects of postnatal steroids or human amnion epithelial cells to treat and prevent brochopulmonary dysplasia. Our results suggest that tapered low-dose steroids reduces lung inflammation and injury, whilst hAECs improve lung morphology and have pro-reparative potential in lung pathology.