10.26180/5c37f28047ad6 PAULO CESAR PINARES-GARCIA PAULO CESAR PINARES-GARCIA The regulation and function of the Y chromosome gene, SRY, in experimental and clinical PD Monash University 2019 Parkinson's disease sex differences neurological disorders SRY male sex bias disease-modifying therapy Neuroscience 2019-03-12 00:58:31 Thesis https://bridges.monash.edu/articles/thesis/The_regulation_and_function_of_the_Y_chromosome_gene_SRY_in_experimental_and_clinical_PD/7575890 Parkinson’s disease (PD) is a debilitating neurodegenerative disorder that results from the death of dopamine-producing cells in the brain. Whilst the cause of PD is unknown, the male-sex is a significant risk factor. My thesis investigated whether the Y-chromosome gene, SRY, contributes to the vulnerability of males to PD. I found that SRY expression is dysregulated in experimental and clinical PD, and that reducing SRY expression can slow the disease progression in multiple animal models of PD. Overall, work from my thesis reveal a novel sex-specific cause for PD and that SRY may be novel therapeutic target for PD.