10.26180/5c898889ebe63 PEI KEE GOH PEI KEE GOH The role of TCPTP in Mammary gland development and tumorigenesis Monash University 2019 TCPTP mammary gland immune STATs signalling Biochemistry 2019-03-13 22:47:36 Thesis https://bridges.monash.edu/articles/thesis/The_role_of_TCPTP_in_Mammary_gland_development_and_tumorigenesis/7841321 One of the drivers of triple negative breast cancer is mediated by aberrant EGFR/STAT3 signalling. The findings of this study support a model in which TCPTP deletion in mammary gland results in PTK/STAT3 hyperactivation that contributes to pre-malignant changes. Despite the pro-tumorigenic effects, the findings in this study also define a role for TCPTP to harness the host immune system to potentially impede tumour progression. The results presented in this study are the first to explore the dichotomous roles of TCPTP in tumorigenesis and its interactions with the immune system.