10.26180/5d0316cc60c1b MARY AIDA AJAMIAN MARY AIDA AJAMIAN Investigating Markers of Intestinal Barrier Dysfunction in Gastrointestinal Diseases Monash University 2019 Medicine Gastroenterology and Hepatology Immunology Leaky Gut Biomarkers Non-Coeliac Wheat Sensitivity Coeliac Disease Ulcerative Colitis Zonulin Syndecan-1 I-FABP LBP sCD14 FODMAP Exercise-Induced Gastrointestinal Syndrome Intestinal permeability Intestinal barrier Microbial transloaction Bacterial translocation Gastroenterology and Hepatology Immunology Medicine 2019-06-14 03:38:50 Thesis https://bridges.monash.edu/articles/thesis/Investigating_Markers_of_Intestinal_Barrier_Dysfunction_in_Gastrointestinal_Diseases/8273861 This thesis studies circulating biomarkers of intestinal epithelial barrier integrity and function in human models. The results reveal that the protein zonulin, as it currently stands, is not a useful marker. However, a combination of other markers indicative of epithelial injury and and bacterial translocation provide insights into the heterogeneity of barrier dysfunction, localisation of intestinal injury, and modulation of the intestinal epithelium by diet and other factors.