Improving the design, reporting and statistical methods used in cluster randomised crossover trials SARAH JANE ARNUP 10.26180/5d15764f5d278 https://bridges.monash.edu/articles/thesis/Improving_the_design_reporting_and_statistical_methods_used_in_cluster_randomised_crossover_trials/8341160 The cluster randomised crossover (CRXO) design is a type of randomised trial that is used to assess the effects of interventions. The aim of this research was to assess the design, reporting quality, and statistical methods used in CRXO trials, and to facilitate improvement where shortcomings were identified. The research showed that incomplete reporting and the application of inappropriate methods for sample size calculation and analysis were common. This resulted in the development of graphical illustrations that explained the intuition behind the design, a proposal for a reporting guideline, detailed sample size considerations and sample size formulae for stratified trials. 2019-06-28 02:07:09 Cluster randomised trials crossover randomised trials sample size calculation trial design statistical analysis reporting quality intracluster correlation Biostatistics