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A Spectroscopic investigation into the binding of novel Platinum(IV) and Platinum(II) anticancer drugs with DNA and cells
thesis
posted on 2017-05-07, 23:53 authored by PRAVINDYA RUKSHANI HAPUTHANTHRIHere in, we describe the development of vibrational micro-spectroscopy techniques such as infrared spectroscopy and Synchrotron Far IR spectroscopy and Raman spectroscopy for the characterization of platinum (IV) and (II) complexes, which are used as anti-cancer drugs. A translational approach utilising the latest development in spectroscopic techniques is developed to understand chemotherapeutic interactions with DNA and cell cultures. The efficacy of using platinum (IV) and (II) based complexes has been examined by spectroscopically monitoring the accumulation of the drug in cells with the application of multivariate analysis. In addition, computational calculations were performed for a range of platinum complexes to understand their vibrational spectra.
History
Campus location
AustraliaPrincipal supervisor
Donald McnaughtonAdditional supervisor 1
Bayden R. WoodAdditional supervisor 2
Glen B. DeaconYear of Award
2017Department, School or Centre
ChemistryCourse
Doctor of PhilosophyDegree Type
DoctorateFaculty
Faculty of ScienceUsage metrics
Categories
- Oncology and carcinogenesis not elsewhere classified
- Biochemistry and cell biology not elsewhere classified
- Inorganic chemistry not elsewhere classified
- Plant cell and molecular biology
- Animal cell and molecular biology
- Medical biotechnology not elsewhere classified
- Analytical chemistry not elsewhere classified
- Physical chemistry not elsewhere classified
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