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Reason: Under embargo until August 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
A functional and structural investigation of the pro- and anti-viral roles of the DDX3 DEAD-box RNA helicases
thesis
posted on 2018-08-16, 06:42 authored by STEVEN MATTHEW HEATONDuring infection, our immune system triggers drastic but highly regulated changes in gene activity to bring about protective immune responses. This thesis identifies, dissects and challenges the molecular mechanisms by which DDX3 interacts with the cell nucleus and controls the two main signalling and effector arcs of the human innate immune system. Several incurable viruses weaponise DDX3 and thereby hack into a nexus of immune and other cellular functions to service their own replication; we now adapt this concept and turn it against these very viruses to develop new treatments.
