Adenosine A2B Receptor Pharmacology and its Role in Pathophysiology

2017-08-14T23:55:03Z (GMT) by ELIZABETH ANN VECCHIO
The adenosine A2B receptor is an important but poorly understood drug target. This thesis investigated new paradigms of adenosine A2B receptor signalling and behaviour and identified drugs that could selectively promote beneficial outcomes in prostate cancer cells and cardiac fibroblasts. This information helps to inform how targeting the adenosine A2B receptor may be used as a treatment for prostate cancer and cardiovascular disease.