Multivalent Ligands as Chemical Probes for the Investigation of Dopamine D2 Receptor Pharmacology

2017-09-10T23:44:40Z (GMT) by ANITHA KOPINATHAN
The dopamine D2 receptor is a well-established therapeutic target for the treatment of central nervous system disorders such as schizophrenia and Parkinson’s disease. Although a number of treatments have been developed to target this receptor, our understanding of the structural and pharmacological aspects of the dopamine D2 receptor are still in its infancy. This thesis describes the design, synthesis and biological evaluation of chemical probes to investigate the structure and pharmacology of the dopamine D2 receptor. Through this work, it is envisaged that these probes will aid the development of novel treatments for central nervous system disorders with reduced side-effects.