Monash University
Browse

Restricted Access

Reason: Access restricted by the author. A copy can be requested for private research and study by contacting your institution's library service. This copy cannot be republished

Novel method for measuring anatomical dead space as a potential means of assessing airway distensibility

thesis
posted on 2019-08-14, 01:55 authored by David Peter Jones
This thesis describes the development and application of a new, noninvasive method for providing in-vivo measurements of anatomical dead space (VD), and its components in cooperative human subjects. It also investigates their relationships with changing lung volume (airway distensibility, AVD) in normal versus asthmatic subjects. The computerised method for measuring VD was based on CO2 washout, with tidal breathing, at discrete, or progresnively increasing or decreasing lung volumes between TLC or RV. Absolute lung volume (TLC or RV), determined by body plethysmography, was used in the computer calculation of AVD as the reference volume to obtain end-inspiratory lung volume for each measurement of anatomical VD. This new method provided rapid measurements of VD, with duplicate measurements taking 10-15 minutes to complete, even in untrained subjects.[…]

History

Principal supervisor

Principal supervisor

Additional supervisor 1

E. Hayden Walters

Additional supervisor 2

Richard Harding

Additional supervisor 3

John Wilson

Year of Award

1998

Department, School or Centre

Respiratory Medicine

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine, Nursing and Health Sciences