Thesis QN Final.pdf (45.87 MB)
Reproducing Spermatogenesis
thesis
posted on 2017-08-29, 00:02 authored by Queenie V. NeriGerm
cells isolated from testicular tissue or derived from embryonic stem cells
represent a possible treatment option for children who have survived cancer and
for azoospermic men. Self-renewal of spermatogonia stem cells is the foundation
for sustaining spermatogenesis throughout life. In recent years, spermatogonia
transplantation in mammals has been carried out successfully and, more
recently, the appearance of germ cell lines derived from embryonic stem cells
has rendered the treatment or prevention of azoospermia conceivable. In our
laboratory, we have identified and labeled human spermatogenic cells at various
steps of differentiation and carried out their xenogeneic transplantation into
recipient gonads. In addition, by appropriately modifying culture conditions,
we have been able to propagate mouse spermatogonia stem cells in vitro.
History
Principal supervisor
Graham JenkinAdditional supervisor 1
David De KretserYear of Award
2017Department, School or Centre
Clinical Sciences at Monash HealthAdditional Institution or Organisation
Obstetrics and GynaecologyCampus location
AustraliaCourse
Doctor of PhilosophyDegree Type
DOCTORATEFaculty
Faculty of Medicine Nursing and Health SciencesUsage metrics
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