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Reason: Under embargo until September 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

T cell polarisation in the Preterm Infant and its Impact on Bronchopulmonary Dysplasia

thesis
posted on 2019-09-03, 05:12 authored by CHUN WANG JASON LAO
The chronic lung disease BPD is common in preterm babies, i.e. those born about two-thirds through a normal pregnancy. These babies are dependent on supplemental oxygen for months to years, and their doctors have no effective therapy. I examined blood samples from 51 preterm babies at birth and 4 other time points and found that BPD babies have specific immune polarisation patterns. This finding provides a new understanding of the process driving BPD and lays the foundation for repurposing of a group of existing medicines for use in these tiny patients, bringing hope for relief from this devastating disease.

History

Principal supervisor

Marcel Nold

Additional supervisor 1

Claudia Nold

Additional supervisor 2

Ina Rudloff

Additional supervisor 3

Niamh Mangan

Year of Award

2019

Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation

Paediatrics

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences