File(s) under permanent embargo
Reason: Under embargo until October 2018. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library or by emailing document.delivery@monash.edu
Targeted Delivery of Small Interfering RNA (siRNA) Against Oncogenes by using pH-Sensitive Nanoparticles to Inhibit Breast Cancer Cells Proliferation and Survival
Version 2 2019-06-21, 06:05
Version 1 2017-10-17, 06:15
thesis
posted on 2017-10-17, 06:15 authored by NUR IZYANI KAMARUZMANHarnessing siRNA technology has promising results in limiting the proliferation and survival of cancer cells by ‘silencing’ the expression of targeted genes. Carbonate apatite nanoparticle system has been employed to electrostatically complex with the siRNAs in order to prevent their degradation and renal clearance, and enhance the uptake by target cells following intravenous administration. This study would have significant impact in validating the potential applications of pH-sensitive carbonate apatite nanoparticles for delivery of siRNA cocktails in different models of breast cancer as well as in clinical trials.
