The Investigation of Red Cell Mutants Identified in an ENU Mutagenesis Screen

2019-03-14T04:05:03Z (GMT) by ASHLEE JADE CONWAY
This thesis describes the study of mutant mice which harbour congenital defects in various aspects of erythropoiesis, obtained through ENU mutagenesis. Mice were phenotyped and characterised in order to understand the underlying genetic and molecular mechanisms which resulted in their red cell defects, as well as their clinical relevance to human red cell diseases.