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Reason: Under embargo until November 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Understanding the Lung Clearance Kinetics and Disposition of Inhaled Biodegradable Nanomedicines
thesis
posted on 2018-11-12, 02:35 authored by SHADABUL HAQUEInhalable nanomedicines based on biodegradable lipid- or polymer-based nanomaterial drug carriers are rapidly being advanced through preclinical and clinical trials. Despite this, there is still a fundamental lack of understanding about how biodegradable or erodible nanoparticles and polymeric drug carriers are cleared from healthy and diseased lungs. This thesis comprehensively evaluates the pharmacokinetic behavior, patterns of lung clearance and immunological responses of the lungs to inhaled biodegradable nanoparticles that have been extensively explored pre-clinically as inhalable nanomedicines. This thesis also describes and compares the biopharmaceutical behaviour of inhaled nanomedicines in healthy and diseased lungs.